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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
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Recent Advances in the Surfactant and Controlled Release Polymer-based Solid Dispersion.

Aman Gupta1,2, Gourav Paudwal1,3, Rigzin Dolkar1,3

  • 1PK-PD Tox & Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu-180002, India.

Current Pharmaceutical Design
|February 25, 2022
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Summary

Solid dispersion (SD) enhances oral drug bioavailability by improving solubility. Novel carriers and methods in SD technology increase therapeutic effectiveness for insoluble drugs.

Keywords:
Solid dispersionbioavailabilitydissolution ratepolymeric carriersolubility enhancementsurfactants

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Materials Science

Background:

  • Oral drug administration is preferred due to cost, compliance, and safety.
  • Poor solubility and dissolution limit oral bioavailability of new drug molecules.
  • Solid dispersion (SD) is a key technique for enhancing solubility and bioavailability.

Purpose of the Study:

  • To review recent advancements in solid dispersion (SD) technology.
  • To highlight the role of novel carriers and preparation methods.
  • To discuss the application of SD in improving drug properties and therapeutic response.

Main Methods:

  • Review of current literature on solid dispersion formulations.
  • Analysis of surfactant and controlled-release polymer-based SDs.
  • Evaluation of methods for modifying drug physical properties.

Main Results:

  • SD technology effectively addresses poor solubility and dissolution issues.
  • Novel polymeric carriers and preparation techniques improve oral bioavailability.
  • SD formulations demonstrate enhanced therapeutic effectiveness across various ailments.

Conclusions:

  • Recent generations of SDs, particularly those using surfactants and controlled-release polymers, offer significant advantages.
  • The choice of polymeric carriers and preparation methods is crucial for optimizing SD performance.
  • SD technology holds great potential for improving the clinical applicability of poorly soluble drugs.