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Improving Translational Accuracy

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

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Related Experiment Video

Updated: Oct 2, 2025

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How to embed quality improvement into medical training

Peter Davey¹, Shobhan Thakore², Vicki Tully^1,3

¹University of Dundee Medical School, Dundee, UK.

BMJ (Clinical Research Ed.)

|February 25, 2022

Summary

No abstract available in PubMed .

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