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Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
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Kidney Histopathologic Spectrum and Clinical Indicators Associated with MGRS
Zi-Hao Yong1,2,3,4,5, Xiao-Juan Yu1,2,3,4, Jing-Xia Liu6
1Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People's Republic of China.
Clinical Journal of the American Society of Nephrology : CJASN
|February 25, 2022
Summary
Monoclonal gammopathy of renal significance (MGRS) affects 38% of patients with monoclonal gammopathy and kidney disease. Monoclonal Ig amyloidosis is the leading MGRS cause, associated with abnormal free light chain ratio, older age, and proteinuria.
Area of Science:
- Nephrology
- Hematology
- Immunology
Background:
- Monoclonal gammopathy of renal significance (MGRS) involves monoclonal immunoglobulin-related kidney injuries.
- MGRS diagnosis is crucial for patients with monoclonal gammopathy and kidney disease.
Purpose of the Study:
- To investigate the histopathologic spectrum of MGRS.
- To identify clinical characteristics associated with MGRS in Chinese patients.
Main Methods:
- Retrospective study of 700 patients with monoclonal gammopathy and kidney biopsy.
- Exclusion of patients with malignant hematologic diseases.
- Multivariable logistic regression to identify MGRS-associated clinical characteristics.
Main Results:
- 261 patients (38%) had MGRS lesions.
- Monoclonal Ig amyloidosis was the most common MGRS diagnosis (63%).
- Abnormal serum free light chain ratio, older age, and proteinuria were associated with MGRS.
Conclusions:
- Monoclonal Ig amyloidosis is the primary cause of MGRS in Chinese patients.
- Abnormal free light chain ratio, older age, and proteinuria are key indicators for MGRS.
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