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The initial rate of tumour response to vismodegib treatment, can predict a complete response outcome for periocular
Alon Tiosano1,2, Meydan Ben-Ishai3,4, Eyal Fenig5,4
1Department of Ophthalmology, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel. alon.tiosano@gmail.com.
Purpose:
To establish a model to predict treatment outcome of periocular locally advanced basal cell carcinoma (POLA BCC) based on initial response to treatment with vismodegib (ErivedgeTM), a sonic hedgehog inhibitor.
Design:
Subgroup analysis of data from the STEVIE study database.
Methods:
Analysis of medical history, treatment protocol, and treatment outcome of POLA BCC tumours in a STEVIE study population of 244 POLA BCC patients treated with ≥1 dose of vismodegib.
Results:
A predictive model for complete response (CR) was established based on the initial treatment response. A cutoff value of 20% reduction in tumour size at 3 months of treatment identified the patients with a high probability (82.76%) to achieve CR. A second cutoff value of 67.7% reduction in tumour size at 6 months of treatment improved the prediction to a 95.42% probability of a CR outcome.
Conclusions:
A treatment model was constructed based on the prediction of a CR outcome and the initial response to vismodegib treatment at 3 and 6 months. The study result provide significant new insights can facilitate decision-making on treatment management according to tumour response in patients with POLA BCC.
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