Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Yeast Signaling01:28

Yeast Signaling

16.2K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
16.2K
Gene Regulation During Sporulation01:17

Gene Regulation During Sporulation

126
Sporulation is a complex developmental process that allows certain Gram-positive bacteria, such as Bacillus subtilis and Clostridium species, to survive extreme environmental conditions. This process is tightly regulated by a series of signaling cascades and transcriptional controls, ensuring the formation of a highly resistant endospore.Sporulation is triggered by unfavorable conditions, such as nutrient depletion, and is governed by a phosphorelay system. One of the sensor kinases, such as...
126

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Towards the construction of a virtual yeast.

Nature·2026
Same author

The genetics of the many forms of diversity.

Genetics·2026
Same author

Microbial domestication: Farmhouse brewing preserves a hidden reservoir of yeast diversity.

Current biology : CB·2026
Same author

Population-scale chemical response revealed by a barcoded yeast collection.

Nature communications·2026
Same author

The adaptive molecular landscape of reprogrammed telomeric sequences.

Nature communications·2026
Same author

The 2025 Westlake Autumn Symposium for Al Proteomics and Virtual Cell.

Genomics, proteomics & bioinformatics·2026

Related Experiment Video

Updated: Oct 2, 2025

Microscopy of Fission Yeast Sexual Lifecycle
07:47

Microscopy of Fission Yeast Sexual Lifecycle

Published on: March 9, 2016

14.8K

Domestication reprogrammed the budding yeast life cycle.

Matteo De Chiara1, Benjamin P Barré2,3, Karl Persson4

  • 1Université Côte d'Azur, CNRS, INSERM, IRCAN, Nice, France. matteo.de-chiara@univ-cotedazur.fr.

Nature Ecology & Evolution
|February 25, 2022
PubMed
Summary

Domestication significantly altered yeast Saccharomyces cerevisiae biology, enhancing fermentation and impairing sexual reproduction. This domestication syndrome, driven by genetic changes, impacts our understanding of this model organism's natural state.

More Related Videos

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast
06:53

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast

Published on: February 21, 2025

583
Determination of the Mating Efficiency of Haploids in Saccharomyces cerevisiae
05:39

Determination of the Mating Efficiency of Haploids in Saccharomyces cerevisiae

Published on: December 2, 2022

2.6K

Related Experiment Videos

Last Updated: Oct 2, 2025

Microscopy of Fission Yeast Sexual Lifecycle
07:47

Microscopy of Fission Yeast Sexual Lifecycle

Published on: March 9, 2016

14.8K
In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast
06:53

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast

Published on: February 21, 2025

583
Determination of the Mating Efficiency of Haploids in Saccharomyces cerevisiae
05:39

Determination of the Mating Efficiency of Haploids in Saccharomyces cerevisiae

Published on: December 2, 2022

2.6K

Area of Science:

  • Microbiology
  • Evolutionary Biology
  • Genetics

Background:

  • Domestication profoundly impacts species biology, serving as a foundation for global food supply.
  • The yeast Saccharomyces cerevisiae is a crucial model organism in biological research.

Purpose of the Study:

  • To investigate the species-wide effects of domestication on Saccharomyces cerevisiae.
  • To identify genetic factors underlying the yeast domestication syndrome.

Main Methods:

  • Analysis of sexual and asexual reproduction and chronological life span in 1,011 genome-sequenced yeast isolates.
  • Genome-wide association analysis and genetic engineering to trace genetic origins.
  • Comparative analysis of domesticated and wild yeast strains.

Main Results:

  • A clear dichotomy was observed between domesticated and wild yeast strains.
  • Domestication enhanced fermentative growth, reduced respiratory growth, altered stress tolerance, and impaired sexual reproduction.
  • Chronological life span was clade-specific, not significantly affected by domestication.
  • Genetic factors including aneuploidy, gene copy number variations, and SNPs were identified as causative.

Conclusions:

  • Domestication represents a major evolutionary event in Saccharomyces cerevisiae.
  • The domestication syndrome has significantly altered the biology of this model yeast.
  • Understanding these alterations is crucial for interpreting research using domesticated yeast strains.