Hemoglobin A1c and Angiographic Severity with Coronary Artery Disease: A Cross-Sectional Study
Yugang Yan1,2, Ronghua Gao3, Shaohui Zhang3
1School of Medical Engineering, Jining Medical University, Jining, Shandong, People's Republic of China.
Insights
Higher glycated hemoglobin (HbA1c) levels correlate with increased coronary artery disease (CAD) complexity. Medications like statins and ARBs may influence this relationship, impacting lesion severity evaluation.
Area of Science:
- Cardiology
- Endocrinology
- Medical Research
Background:
- Glycated hemoglobin (HbA1c) is linked to coronary artery disease (CAD).
- HbA1c shows independent association with angiographic severity in Chinese CAD patients.
- Traditional cardiovascular drugs might influence the HbA1c-CAD severity relationship.
Purpose of the Study:
- To investigate the association between HbA1c levels and coronary lesion complexity.
- To explore the impact of cardiovascular medications on this association.
Main Methods:
- Retrospective study of 572 CAD patients undergoing coronary angiography.
- HbA1c levels measured, and coronary lesion complexity assessed using Syntax score.
- Patients stratified by HbA1c quartiles; medication history analyzed.
Main Results:
- A positive association found between HbA1c and Syntax score (β = 1.09, P = 0.0096) after adjusting for confounders.
- Significant interactions observed with statin and angiotensin receptor blocker (ARB) medication history (P < 0.05).
Conclusions:
- HbA1c levels positively correlate with SYNTAX score in CAD patients.
- Oral statins and ARBs modify the correlation between HbA1c and coronary lesion complexity.
- HbA1c can aid in evaluating coronary lesion severity and complexity in CAD.
Background:
Many studies have shown that glycated hemoglobin (HbA1c) is associated with coronary artery disease (CAD). HbA1c was independently related to angiographic severity in Chinese patients with CAD after adjusting for other covariates. Some traditional cardiovascular drugs may have an impact on this relationship.
Methods:
This retrospective study enrolled a total of 572 CAD patients who underwent their coronary angiography and had their HbA1c levels measured at the Chinese Hospital. The complexity of the coronary artery lesions was evaluated using the Syntax score, and the subjects were divided into 4 inter quartiles according to HbA1c levels. Covariates included history of traditional cardiovascular drugs.
Results:
The average age of selected participants was 61.00 ± 9.15 years old, and about 54.72% of them were male. Result of fully adjusted linear regression showed that HbA1c was positively associated with Syntax score after adjusting confounders (β = 1.09, 95% CI: 0.27, 1.91, P = 0.0096). By interaction and stratified analyses, the interactions were observed based on our specification including with the medication history of statins and angiotensin receptor blockers (ARBs) (P values for interaction <0.05).
Conclusion:
In this study, we found a positive correlation between the HbA1c levels and the SYNTAX score among CAD individuals, and oral statins and ARBs medication could affect the correlation. Thus, HbA1c measurement could be used for the evaluation of the severity and complexity of coronary lesions among CAD patients.
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