Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Protein-protein Interfaces02:04

Protein-protein Interfaces

13.9K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
13.9K
Ligand Binding Sites02:40

Ligand Binding Sites

13.9K
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
13.9K
Protein Networks02:26

Protein Networks

4.1K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.1K
Improving Translational Accuracy02:07

Improving Translational Accuracy

2.8K
2.8K
Wilcoxon Signed-Ranks Test for Matched Pairs01:09

Wilcoxon Signed-Ranks Test for Matched Pairs

232
The Wilcoxon signed-rank test for matched pairs evaluates the null hypothesis by combining the ranks of differences with their signs. It essentially tests whether the median of the differences in a population of matched pairs is zero. Since the test incorporates more information than the sign test, it generally yields more trustable conclusions. This test also does not require the data to follow a normal distribution, but two conditions must be met for it to be applicable: (1) the data must...
232

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Book Club at a medical school in the Sertão Region of Rio Grande do Norte State, Brazil.

Journal of the Medical Library Association : JMLA·2026
Same journal

Implementing a Spanish Wikipedia elective for medical students.

Journal of the Medical Library Association : JMLA·2026
Same journal

Comparing the performance of narrow vs. broad search strategies when using machine learning-based software for title/abstract screening.

Journal of the Medical Library Association : JMLA·2026
Same journal

Expert-recommended tasks for hospital librarians during a healthcare system merger or acquisition: an e-Delphi consensus statement.

Journal of the Medical Library Association : JMLA·2026
Same journal

Building an interactive dashboard to visualize institutional open access publishing trends.

Journal of the Medical Library Association : JMLA·2026
Same journal

Evaluating automated or artificial intelligence search tools for evidence synthesis.

Journal of the Medical Library Association : JMLA·2026

Related Experiment Video

Updated: Oct 2, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

644

Artificial intelligence behind the scenes: PubMed's Best Match algorithm.

Lucy Kiester1, Clara Turp2

  • 1lucy.kiester@mcgill.ca, Liaison Librarian, McGill University Library, Montreal, Quebec, Canada.

Journal of the Medical Library Association : JMLA
|February 25, 2022
PubMed
Summary

PubMed's Best Match algorithm uses artificial intelligence (AI) to sort search results, potentially impacting healthcare providers. Understanding AI's influence on search relevance and bias is crucial for clinical decision-making.

Keywords:
Best MatchPubMedartificial intelligenceinformation systemsinformation-seeking behavior

More Related Videos

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

69.1K
A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

1.8K

Related Experiment Videos

Last Updated: Oct 2, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

644
A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

69.1K
A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

1.8K

Area of Science:

  • Bibliometrics
  • Health Informatics
  • Artificial Intelligence

Background:

  • PubMed implemented an "Best Match" algorithm in 2020, defaulting to AI-driven sorting.
  • Users are often unaware of AI's role in shaping their search results.
  • The increasing reliance on AI necessitates an examination of its impact on information retrieval.

Purpose of the Study:

  • To demystify PubMed's Best Match algorithm and its AI components.
  • To analyze user search behaviors in the context of AI-driven results.
  • To discuss the ethical implications of AI algorithms in healthcare search.

Main Methods:

  • Simplified explanation of the Best Match algorithm's functionality.
  • Discussion of user search patterns and AI influence.
  • Ethical analysis of algorithmic bias and transparency.

Main Results:

  • AI significantly influences search result sorting in ways users may not perceive.
  • The default use of AI raises concerns about potential bias and suppression of relevant information.
  • Healthcare practitioners may be particularly affected due to reliance on initial search results.

Conclusions:

  • The integration of AI in PubMed's Best Match algorithm requires critical evaluation.
  • Ensuring unbiased and transparent AI in healthcare search is paramount.
  • Further research is needed to understand and mitigate potential negative impacts of AI on clinical decision-making.