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Updated: Oct 2, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Artificial intelligence behind the scenes: PubMed's Best Match algorithm
1lucy.kiester@mcgill.ca, Liaison Librarian, McGill University Library, Montreal, Quebec, Canada.
Abstract:
This article focuses on PubMed's Best Match sorting algorithm, presenting a simplified explanation of how it operates and highlighting how artificial intelligence affects search results in ways that are not seen by users. We further discuss user search behaviors and the ethical implications of algorithms, specifically for health care practitioners. PubMed recently began using artificial intelligence to improve the sorting of search results using a Best Match option. In 2020, PubMed deployed this algorithm as the default search method, necessitating serious discussion around the ethics of this and similar algorithms, as users do not always know when an algorithm uses artificial intelligence, what artificial intelligence is, and how it may impact their everyday tasks. These implications resonate strongly in health care, in which the speed and relevancy of search results is crucial but does not negate the importance of a lack of bias in how those search results are selected or presented to the user. As a health care provider will not often venture past the first few results in search of a clinical decision, will Best Match help them find the answers they need more quickly? Or will the algorithm bias their results, leading to the potential suppression of more recent or relevant results?
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