Related Experiment Video
Updated: Oct 2, 2025

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
Published on: May 17, 2024
Trichoblastic fibroma mimicking sarcoma
1Department of General Surgery, Calvary Public Hospital, Canberra 2601, Australia.
Abstract:
Trichoblastic fibroma (TF) is a benign trichogenic tumour that has both epithelial and mesenchymal components and exhibits partial to complete follicular induction.TF is rare and in our case it is mimicking sarcoma. We report a 35-year-old gentleman who presented with a lump over his left lower leg for the last 15 years. The lump was gradually increasing in size with a slight discomfort, no pain or any other symptoms. Consequently, the patient had an ultrasound which revealed bilobed solid lesion, and ultrasound-guided core biopsy revealed basaloid neoplasm. After positron emission tomography scan and discussion in MDT wide local excision performed. The histopathology revealed TF. Hence, TF should be included in differential diagnosis of relative superficial suspicious sarcomas. If there is any suspicion and changes in behaviour of long-term stable nodules they should be excised with a clear margin as there are aggressive TF reported in the literature.

