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Updated: Oct 2, 2025

Identification of Circular RNAs using RNA Sequencing
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Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

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Recent advances in crosstalk between N6-methyladenosine (m6A) modification and circular RNAs in cancer

Xin Huang1, Haoyu Guo1, Lutong Wang1

  • 1Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road 1277, Wuhan 430022, China.

Molecular Therapy. Nucleic Acids
|February 25, 2022
PubMed

Insights

N6-methyladenosine (m6A) RNA modifications and circular RNAs (circRNAs) interact to influence cancer development. Understanding this crosstalk offers new avenues for cancer diagnosis and treatment.

Area of Science:

  • Molecular Biology
  • Oncology
  • Epigenetics

Background:

  • N6-methyladenosine (m6A) is the most prevalent RNA modification, crucial in cancer.
  • Circular RNAs (circRNAs) are emerging regulators in biological processes.
  • m6A modification influences circRNA functions, and circRNAs target m6A regulators.

Purpose of the Study:

  • To review the functional crosstalk between m6A and circRNAs in cancer.
  • To illustrate the roles of m6A and circRNAs in cancer development.
  • To discuss potential applications and future research directions.

Main Methods:

  • Literature review of existing studies on m6A, circRNAs, and cancer.
  • Analysis of the mechanisms by which m6A affects circRNAs (biogenesis, stability, export).
  • Examination of how circRNAs regulate m6A regulators and target mRNAs.

Main Results:

  • m6A methylation impacts circRNA biogenesis, stability, and cytoplasmic export across various cancers.
  • circRNAs modulate the expression and degradation of m6A regulators.
  • circRNAs influence m6A modification of target mRNAs, affecting cancer progression.

Conclusions:

  • The interplay between m6A and circRNAs is integral to cancer development.
  • Further research into m6A and circRNAs can yield novel insights for cancer diagnosis and therapy.
  • Targeting this crosstalk presents potential therapeutic strategies for cancer patients.
Keywords:
N6-methyladenosine modificationcircular RNAsdrug resistancemetastasisradiotherapy tolerancetumorigenesis

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