Related Experiment Video
Updated: Oct 2, 2025
08:40
Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
Published on: March 1, 2019
59.2K
SP-D and CC-16 Pneumoproteins' Kinetics and Their Predictive Role During SARS-CoV-2 Infection.
Margherita Tiezzi1,2, Sofia Morra1,3, Jimmy Seminerio1
1Department of Cardiology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Frontiers in Medicine
|February 25, 2022
Summary
Increased surfactant protein D (SP-D) levels predict better outcomes for COVID-19 patients, while higher pulmonary club cell protein 16 (CC-16) levels indicate a greater risk of death. These pneumoproteins aid in predicting patient prognosis.
Area of Science:
- Pulmonary medicine
- Critical care
- Infectious disease
Background:
- Surfactant protein D (SP-D) and pulmonary club cell protein 16 (CC-16) are key pneumoproteins involved in host defense.
- These proteins play roles in managing oxidative stress, inflammation, and viral infections.
Purpose of the Study:
- To evaluate the predictive value of SP-D and CC-16 for acute respiratory distress syndrome (ARDS) or mortality in COVID-19 patients.
- To assess the prognostic significance of these pneumoproteins in severe respiratory illness.
Main Methods:
- Retrospective analysis of 87 COVID-19 patients.
- Measurement of SP-D and CC-16 serum levels at hospital admission and on days 5 and 14.
- Multivariate analysis incorporating clinical confounders.
Main Results:
- Initial SP-D levels showed a slight positive correlation with ARDS development.
- Elevated CC-16 levels on day 1 correlated with an increased risk of fatal outcome.
- A rise in SP-D levels between days 1 and 5/14 strongly predicted a lower incidence of ARDS.
Conclusions:
- Increasing SP-D levels serve as a positive prognostic indicator in COVID-19.
- Initial CC-16 levels are associated with a slightly elevated risk of mortality.
- SP-D and CC-16 show potential utility in predicting COVID-19 patient outcomes.
Related Concept Videos
01:29Pneumonia II: Pathophysiology
883
The pathophysiology of pneumonia involves the following steps:
883
02:50Conjugated Proteins
19.0K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
19.0K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
3.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
3.2K
01:20COPD: Pathogenesis and Clinical Features
662
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
662
01:05Single Nucleotide Polymorphisms-SNPs
16.5K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
16.5K
01:23Cystic Fibrosis: Pathogenesis
384
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
384