Related Experiment Video
Updated: Oct 2, 2025
06:15
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
1.4K
Primary orbital monophasic synovial sarcoma with calcification: A case report.
Ming-Yu Ren1, Jing Li2, Rui-Miao Li3
1Department of Orbital Disease and Ocular Tumor, Hebei Eye Hospital, Xingtai 054001, Hebei Province, China. 147237583@qq.com.
World Journal of Clinical Cases
|February 25, 2022
Summary
Primary orbital synovial sarcoma is a rare cancer in children. Early diagnosis requires careful review of clinical, imaging, and pathology for effective treatment.
Area of Science:
- Oncology
- Ophthalmology
- Pathology
Background:
- Synovial sarcoma is a rare malignant mesenchymal neoplasm.
- Primary orbital involvement is exceptionally uncommon, particularly in pediatric patients.
- This tumor exhibits variable epithelial differentiation.
Observation:
- An 8-year-old girl presented with painless proptosis and lacrimation.
- Clinical and imaging findings were non-specific, mimicking benign orbital masses.
- Histopathological and immunohistochemical examination confirmed monophasic synovial sarcoma with calcification.
Findings:
- Monophasic synovial sarcoma with calcification is a rare orbital tumor.
- Clinical and radiological features lack specificity, potentially leading to misdiagnosis.
- Complete surgical resection is the primary treatment modality.
Implications:
- Comprehensive diagnostic analysis integrating clinical, radiological, and pathological data is crucial.
- Prompt diagnosis and surgical intervention are vital for favorable outcomes.
- Adjuvant or neoadjuvant radiotherapy may be considered for localized tumors.
Related Concept Videos
01:29Bone Disorders
4.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.1K
01:07Development of the Limb Synovial Joints
1.7K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
1.7K
01:19Bones of the Upper Limb: Humerus
5.1K
The upper limb consists of the arm, forearm, wrist, and hand bones. The humerus is the single bone of the upper arm region. Proximally, it has a large, spherical, smooth head that articulates with the glenoid cavity of the scapula to form the glenohumeral or shoulder joint. The margin of the head is the anatomical neck, a residual epiphyseal plate. Laterally it extends to form bony projections called the greater tubercle and the lesser tubercle. Next to the tubercles is the surgical neck, a...
5.1K
01:09Bones of the Upper Limb: Radius
3.3K
The radius is longer of the two bones that make up the human antebrachium or forearm. At the proximal end, the radius articulates with the capitulum of the humerus and the radial notch of the ulna to form the elbow joint. At the distal end, the radius articulates with the ulna via the ulnar notch, forming the distal radioulnar joint. Distally, the radius also attaches to the carpal wrist bones (scaphoid and lunate) to form the radiocarpal joint.
The radius has a nail-shaped head, and a...
The radius has a nail-shaped head, and a...
3.3K