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An Instructive Case of Cerebral Mucormycosis
Belinda Shao1, Matthew J Hagan2, Rahul A Sastry1
1Department of Neurosurgery, Warren Alpert Medical School of Brown University, Providence, RI.
Rhode Island Medical Journal (2013)
|February 25, 2022
Summary
Mucormycosis, a deadly fungal infection, was diagnosed postmortem in a diabetic patient with COVID-19. High steroid use during COVID-19 treatment necessitates considering mucormycosis in high-risk patients with rapid decline.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Neurology
Background:
- Mucormycosis is a severe fungal infection with high mortality.
- Rhinocerebral mucormycosis presents a significant clinical challenge.
Observation:
- A diabetic patient with recent COVID-19 pneumonia developed altered mental status.
- Initial imaging suggested a brain neoplasm, but autopsy revealed cerebral mucormycosis.
Findings:
- The patient exhibited rapid neurological decline and persistent hyperglycemia.
- Nasal sinusitis and aggressive intracranial disease supported the mucormycosis diagnosis.
Implications:
- Cerebral mucormycosis should be considered in immunocompromised patients, especially those with diabetes and recent COVID-19.
- Increased corticosteroid use in COVID-19 management may elevate mucormycosis risk.
