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Monitoring iron stores in Icelandic blood donors from 1997 through 2019
Erla Gestsdottir1, Magnus Karl Magnusson1,2, Sigrun Helga Lund2
1Department of Medicine, Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
Objectives:
To estimate the frequency of iron deficiency (ID) and anaemia in blood donors in Iceland and the impact of serum ferritin (SF) testing policy change.
Background:
Blood donations contribute to ID and/or anaemia in whole blood donors (WBD). SF may be used to monitor blood donor iron stores.
Materials And Methods:
The study included WBD and new donors (ND) in the Icelandic Blood Bank in 1997-2019. SF was measured for ND and intermittently for WBD until October 2017, but thereafter for all WBD and ND at every visit. In January 2018, the SF threshold increased from 14 to 16 μg/L for ND and from 8 to 10 μg/L for WBD.
Results:
The study included 85 370 SF results from 243 369 visits of 32 910 donors. Median SF was higher for males than females, both for ND (88.0 vs. 31.2 μg/L, p < 0.001) and WBD (before 2018: 43.0 vs. 22.0 μg/L, p < 0.001). After the policy change in 2018, median SF increased for both male WBD (to 45.2 μg/L, p < 0.001) and female WBD (to 25.7 μg/L, p < 0.001). ID (SF <15 μg/L) was present in 10.6% of female ND and 0.5% of male ND. After policy change, the proportion of WB donations associated with ID decreased for males (from 6.4% to 4.0%) and females (from 18.9% to 14.1%). ID anaemia was present at some time in 3.7% of female WBD and 1.2% of male WBD.
Conclusion:
This nationwide study showed that ID in WB donors is common, especially among females, but monitoring SF may improve donor management.
