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Updated: Oct 2, 2025

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
Pick the best of both glucose and lipid metabolism
Tatsunori Shimizu1, Yuya Takahashi1, Hiroki Fujita1
1Department of Metabolism and Endocrinology, Akita University Graduate School of Medicine, Akita, Japan.
Abstract:
Isthmin-1 is an adipokine that has a potent glucose-lowering effect by stimulating a common intracellular signaling pathway with insulin through a distinct receptor and has an inhibitory effect on lipogenesis in the liver, whereas insulin has the opposite effect. Isthmin-1 is expected to have clinical benefits in the treatment of diabetes.
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