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Natural compounds as safe therapeutic options for ulcerative colitis
Mukta Gupta1, Vijay Mishra2, Monica Gulati1
1School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
Inflammopharmacology
|February 25, 2022
Summary
Natural remedies offer a promising, affordable alternative for ulcerative colitis (UC) treatment, showing fewer side effects than conventional drugs. Further research is needed to confirm the clinical efficacy of these herbal compounds for UC management.
Area of Science:
- Gastroenterology and Hepatology
- Pharmacology and Pharmaceutical Sciences
- Natural Product Chemistry
Background:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited long-term treatment options.
- Conventional UC therapies (corticosteroids, biologics) have significant side effects and often fail to maintain remission.
- Natural remedies present a potentially safer and more affordable approach to managing UC.
Purpose of the Study:
- To review the current literature on the role of herbal drugs in the treatment and potential cure of ulcerative colitis.
- To identify key plant-derived compounds with antiulcerogenic properties relevant to UC management.
Main Methods:
- Comprehensive literature search conducted on Google, PubMed, Web of Science, and Scopus.
- Focused on identifying studies detailing the use of natural products and herbal constituents for UC treatment.
- Reviewed evidence for antiulcerogenic activities of specific plant compounds.
Main Results:
- Natural products have a long history of use in treating UC.
- Key herbal constituents with antiulcerogenic activity include gymnemic acid (Gymnema sylvestre), shagoal (Zingiber officinale), catechin (Camellia sinensis), curcumin (Curcuma longa), arctigenin (Arctium lappa), and boswellic acid (Boswellia serrata).
- These natural remedies offer a potentially effective alternative with fewer side effects compared to conventional treatments.
Conclusions:
- Herbal drugs show significant potential for the treatment and management of ulcerative colitis.
- Specific plant-derived compounds demonstrate promising antiulcerogenic effects.
- Further research into the molecular mechanisms of these natural products is warranted for clinical validation.
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