Molecular neuropathology of brain-invasive meningiomas

Area of Science:

• Neurosurgery
• Oncology
• Pathology

Background:

• Meningioma recurrence is often associated with invasion into brain tissue.
• Brain invasion is a criterion for atypical meningioma (CNS WHO grade 2) but is rarely observed without other high-grade features.
• Brain-invasive otherwise benign (BIOB) meningiomas are controversial, and targeted therapies are lacking.

Purpose of the Study:

• To review mechanisms of meningioma brain invasion.
• To summarize preclinical models for studying targeted therapies against invasive meningiomas.

Main Methods:

• Literature review of mechanisms of meningioma brain invasion.
• Summary of preclinical models investigating targeted therapies for meningioma invasion.

Main Results:

• Meningioma brain invasion is a critical factor in tumor recurrence.
• Current knowledge on invasion mechanisms is compiled.
• Preclinical models for evaluating targeted therapies are summarized.

Conclusions:

• Understanding meningioma invasion mechanisms is crucial for developing effective treatments.
• Targeted therapies for brain-invasive meningiomas require further investigation using preclinical models.