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Effects of Dabigatran on Dementia Pathogenesis and Neuropsychological Function: A Review

Bo-Lin Ho1,2, Sun-Wung Hsieh1,2,3, Ping-Song Chou1,2

  • 1Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Journal of Alzheimer'S Disease : JAD
|February 25, 2022
PubMed

Insights

Non-vitamin K antagonist oral anticoagulants like dabigatran show neutral to positive effects on cognitive and psychological health in atrial fibrillation patients. Further research is needed to confirm these benefits for dementia prevention.

Area of Science:

  • Cardiovascular Pharmacology
  • Neuroscience
  • Geriatric Medicine

Background:

  • Atrial fibrillation (AF) patients face increased risks of cognitive decline and psychological distress.
  • Optimal anticoagulation aims to prevent stroke and systemic thromboembolism while preserving neuropsychological function.

Approach:

  • Systematic literature review of dabigatran's effects on cognitive and psychological outcomes.
  • Searched PubMed/Medline for relevant studies up to August 31, 2021.
  • Included preclinical, observational, and clinical data.

Key Points:

  • Dabigatran demonstrated neutral to positive impacts on cognitive and psychological measures.
  • Observed reduced incidences of anxiety, depression, and dementia in AF patients using dabigatran.
  • Preclinical and observational studies suggest a better therapeutic profile compared to warfarin.

Conclusions:

  • Evidence suggests modest beneficial effects of dabigatran on neuropsychological function.
  • Further clinical trials are essential to validate the pleiotropic protective effects of NOACs against dementia.
Abstract

Keywords:
Anticoagulantatrial fibrillationcognitivedabigatrandementiapsychological function

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