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Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
Published on: March 30, 2020
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Layer-by-Layer Cell Encapsulation for Drug Delivery: The History, Technique Basis, and Applications
Wenyan Li1, Xuejiao Lei1, Hua Feng1
1Department of Neurosurgery, First Affiliated Hospital, Army Medical University, 30 Gaotanyan Street, Chongqing 400038, China.
Pharmaceutics
|February 26, 2022
Summary
Layer-by-layer (LbL) cell encapsulation engineers cellular functions for drug delivery. This technique offers protection and controlled release of bioactive payloads, advancing cell science and biotherapy.
Area of Science:
- Biotechnology
- Materials Science
- Nanotechnology
Background:
- Layer-by-layer (LbL) assembly is a versatile technique for fabricating multilayer films.
- Cell encapsulation using LbL has advanced significantly for cellular function engineering.
Purpose of the Study:
- To comprehensively review the basis and applications of LbL cell encapsulation in drug delivery.
- To highlight the protective effects and controlled payload release capabilities of LbL-encapsulated cells.
Main Methods:
- Review of literature on LbL assembly principles and materials.
- Analysis of LbL cell encapsulation strategies for incorporating bioactive payloads.
- Examination of controlled release mechanisms influenced by environmental and biological factors.
Main Results:
- LbL encapsulation provides protection against adverse factors for encapsulated cells.
- Bioactive payloads can be incorporated into LbL cell constructs.
- Payload delivery can be precisely controlled by environmental stimuli, redox, biological processes, and functional linkers.
Conclusions:
- LbL cell encapsulation is a powerful strategy combining cell and drug activities for enhanced biotherapy.
- This technique holds significant importance for basic cell science research and treating various diseases.
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