Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

6.0K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
6.0K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

2.7K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Hybrid Ensemble System for Time-Series Anomaly Detection in Automated Quality Control of Medical Equipment.

Diagnostics (Basel, Switzerland)·2026
Same author

RVO-ME: A Dual-Task OCT Dataset for Segmentation and Detection of Macular Lesions in Retinal Vein Occlusion.

Scientific data·2026
Same author

Genomic epidemiological analysis reveals new insights into the resurgence of <i>Mycoplasma pneumoniae</i> in China.

Frontiers in cellular and infection microbiology·2025
Same author

Engineering nanopore in monolayer WS<sub>2</sub> for single-molecule imaging on the atomic-scale flat 2D surfaces.

Science advances·2025
Same author

Epidemiological and phylogenetic characteristics of human metapneumovirus in Beijing, China, 2014-2024.

Signal transduction and targeted therapy·2025
Same author

Dibenzononazethrene Isomers: Stable Singlet Diradicaloids with Efficient Photothermal Conversion.

Precision chemistry·2025

Related Experiment Video

Updated: Oct 2, 2025

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

7.3K

CoO Nanozymes with Multiple Catalytic Activities Regulate Atopic Dermatitis.

Mao Mao1,2, Xuejiao Guan1,2, Feng Wu1,2

  • 1School of Life Sciences, Tsinghua University, Beijing 100084, China.

Nanomaterials (Basel, Switzerland)
|February 26, 2022
PubMed
Summary

Cobalt oxide (CoO) nanozymes with SOD-like, CAT-like, and POD-like activities were synthesized. These nanozymes demonstrate biocompatibility and anti-inflammatory effects, offering a promising alternative for treating conditions like atopic dermatitis.

Keywords:
CoOatopic dermatitisenzyme-like catalytic activitynanozyme

More Related Videos

Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment
12:34

Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment

Published on: January 12, 2024

934
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

4.0K

Related Experiment Videos

Last Updated: Oct 2, 2025

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

7.3K
Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment
12:34

Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment

Published on: January 12, 2024

934
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

4.0K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Enzyme Mimics

Background:

  • Oxidative stress from reactive oxygen species (ROS) contributes to inflammation, particularly in atopic dermatitis (AD).
  • Current AD treatments like dexamethasone have significant side effects.
  • Developing novel therapeutic agents with enhanced biocompatibility and reduced toxicity is crucial.

Purpose of the Study:

  • To synthesize cobalt oxide (CoO) nanozymes with multiple enzyme-like activities (superoxide dismutase-like, catalase-like, peroxidase-like).
  • To evaluate the biocompatibility and protective effects of CoO nanozymes against hydrogen peroxide (H2O2)-induced oxidative stress in cells.
  • To investigate the anti-inflammatory potential of CoO nanozymes in an in vivo atopic dermatitis mouse model.

Main Methods:

  • One-pot synthesis of CoO nanoparticles.
  • Surface modification of CoO nanozymes with carboxyl groups to enhance biocompatibility.
  • In vitro assessment of cytotoxicity and protection against H2O2-induced ROS in HaCaT cells.
  • Establishment of an atopic dermatitis mouse model using MC903 topical application.

Main Results:

  • CoO nanozymes were successfully prepared with SOD-like, CAT-like, and POD-like activities.
  • Surface modification improved the biocompatibility of CoO nanozymes.
  • CoO nanozymes effectively protected HaCaT cells from H2O2-induced ROS and cytotoxicity.
  • Topical application of CoO nanozymes demonstrated significant anti-inflammatory effects in the AD mouse model.

Conclusions:

  • This study presents the first report of CoO nanozymes with triple enzyme-like activities synthesized via a one-pot method.
  • Surface-modified CoO nanozymes exhibit low cytotoxicity and potent protective effects against oxidative stress.
  • CoO nanozymes show high potential for therapeutic applications in treating inflammatory diseases like atopic dermatitis with fewer side effects than traditional drugs.