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Pediatric Tuberculosis Research and Development: Progress, Priorities and Funding Opportunities

Lindsay McKenna1, Ani Herna Sari2, Sushant Mane3

  • 1Treatment Action Group, TB Project, New York, NY 10004, USA.

Pathogens (Basel, Switzerland)
|February 26, 2022
PubMed

Insights

Technological advances in pediatric tuberculosis (TB) research are accelerating, but significant gaps remain for children across the care cascade. Increased investment is crucial to advance pediatric TB research and development.

Area of Science:

  • Pediatric infectious diseases
  • Global health research
  • Tuberculosis diagnostics and therapeutics

Background:

  • Pediatric tuberculosis (TB) diagnosis and treatment lag behind adult advancements.
  • The TB care cascade highlights critical research gaps specific to children.
  • Existing research often focuses on adults, leaving pediatric needs underserved.

Purpose of the Study:

  • To review technological advances in pediatric TB research.
  • To identify research gaps in pediatric TB care.
  • To recommend strategies for increased investment in pediatric TB R&D.

Main Methods:

  • Literature review of recent technological innovations in pediatric TB.
  • Analysis of ongoing and completed research in adult TB with pediatric comparisons.
  • Synthesis of expert recommendations for pediatric TB R&D acceleration.

Main Results:

  • Highlighting key technological advancements across the pediatric TB care continuum.
  • Identifying specific research gaps in diagnostics, treatment, and prevention for children.
  • Outlining opportunities for enhanced pediatric TB research and development.

Conclusions:

  • Technological progress in pediatric TB research is evident but requires focused acceleration.
  • Addressing identified research gaps is essential for improving child TB outcomes.
  • Increased investment and strategic partnerships are vital to advance pediatric TB R&D.

Keywords:
R&Dinnovationpediatric TBresearch and development

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