Related Experiment Video

Updated: Oct 2, 2025

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.0K

Non-Canonical Host Intracellular Niche Links to New Antimicrobial Resistance Mechanism

Michaela Kember1, Shannen Grandy1, Renee Raudonis1

  • 1Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada.

Pathogens (Basel, Switzerland)
|February 26, 2022
PubMed

Insights

Antimicrobial resistance is a growing threat. This review explores the intracellular life cycles of resistant bacteria like Pseudomonas aeruginosa and Staphylococcus aureus, and strategies to combat them.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Drug Resistance

Background:

  • Infectious diseases remain a leading cause of death globally.
  • Antimicrobial resistance (AMR) poses a significant threat, potentially rendering current treatments ineffective.
  • New antibacterial strategies are urgently needed to combat resistant pathogens.

Purpose of the Study:

  • To review the non-canonical intracellular life cycle of *Pseudomonas aeruginosa* and *Staphylococcus aureus*.
  • To discuss bacterial factors influencing intracellular survival and AMR.
  • To explore host immunity boosting as a combination therapy and general AMR mitigation strategies.

Main Methods:

  • Literature review of emerging evidence on bacterial intracellular life cycles.
  • Analysis of bacterial factors contributing to resistance within intracellular niches.
  • Summary of recent research on host-directed therapies and general AMR strategies.

Main Results:

  • Emerging evidence highlights the non-canonical intracellular life cycle of *P. aeruginosa* and *S. aureus*.
  • Bacterial factors within intracellular niches contribute to antimicrobial resistance.
  • Host immunity boosting shows promise as a combination therapy.

Conclusions:

  • Understanding bacterial intracellular survival is crucial for developing new antibacterial drugs.
  • Combination therapies, including host-directed approaches, are vital for eradicating resistant pathogens.
  • Broader strategies like surveillance and vaccines are essential for mitigating the impact of antimicrobial resistance.
Keywords:
Pseudomonas aeruginosaStaphylococcus aureusantibiotic resistancenon-canonical intracellular pathogen

More Related Videos

Automated, High-Throughput Detection of Bacterial Adherence to Host Cells07:21

Automated, High-Throughput Detection of Bacterial Adherence to Host Cells

Published on: September 17, 2021

3.6K
Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing08:19

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing

Published on: July 7, 2020

10.7K

Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
286
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
116
Transduction01:16

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
240
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.6K
Antibiotic Selection00:57

Antibiotic Selection

Overview
55.9K
Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
3.0K