Microneedle-Based Natural Polysaccharide for Drug Delivery Systems (DDS): Progress and Challenges

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Nanotechnology

Background:

• Traditional transdermal delivery methods include needles, patches, and creams.
• Microneedles (MNs) are low-invasive, 3D biomedical constructs that enhance drug penetration.
• Carbohydrates, with their tunable properties, are ideal biomaterials for MN fabrication.

Purpose of the Study:

• To provide a comprehensive review of carbohydrate-based microneedles for drug delivery.
• To discuss the potential of these systems in sensing and biologics restitution.
• To explore challenges and opportunities for commercializing carbohydrate-based MNs.

Main Methods:

• Systematic review of literature on carbohydrate-based microneedles.
• Analysis of drug delivery strategies and mechanical properties of MNs.
• Evaluation of clinical translation progress and commercialization potential.

Main Results:

• Carbohydrates like hyaluronic acid, chitin, and cellulose are suitable for MN development.
• Carbohydrate-based MNs demonstrate potential for both localized and systemic drug delivery.
• Significant progress has been made, but challenges remain for market introduction.

Conclusions:

• Carbohydrate-based microneedles represent a novel class of topical drug delivery systems.
• These advanced systems hold high potential for future applications in sensing and therapeutics.
• Continued research and development are crucial for overcoming barriers to commercialization.