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Polyelectrolyte Multilayer Films as a Potential Buccal Platform for Drug Delivery
Bissera Pilicheva1,2, Yordanka Uzunova2,3, Maria Marudova4
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 15A Vassil Aprilov Blvd, 4002 Plovdiv, Bulgaria.
Polymers
|February 26, 2022
Summary
Polyelectrolyte multilayer films show promise for buccal drug delivery. These casein-chitosan systems effectively deliver sparingly soluble drugs, demonstrating good stability and mucoadhesion.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Biomedical Engineering
Background:
- Polyelectrolyte multilayers (PEMs) offer versatile platforms for drug delivery applications.
- Buccal drug delivery requires systems with appropriate mucoadhesion, stability, and controlled release profiles.
- Understanding drug properties' influence on PEM performance is crucial for optimizing drug delivery systems.
Purpose of the Study:
- To evaluate polyelectrolyte multilayers (PEMs) as buccal dosage forms.
- To investigate the impact of drug properties on PEM performance for drug delivery.
- To develop and characterize casein-chitosan based PEMs loaded with model drugs.
Main Methods:
- Fabrication of multilayer films using casein and chitosan.
- Incorporation of model drugs: benzydamine, tolfenamic acid, and betahistine.
- Characterization of films: surface pH, moisture content/absorption, swelling, mucoadhesion, surface morphology, and drug physical state.
Main Results:
- Developed PEMs exhibited non-irritant surface pH within the physiological range.
- Films demonstrated physical stability with low moisture content (<5%) and absorption.
- High mucin adsorption (60-70%) confirmed mucoadhesive properties.
- Drug release kinetics correlated with swelling behavior and were significantly influenced by drug solubility.
- High drug loading was achieved, particularly for sparingly soluble drugs.
Conclusions:
- Casein-chitosan based PEMs are suitable for buccal drug delivery.
- These systems are physically stable, non-irritant, and exhibit significant mucoadhesion.
- PEMs are optimal for delivering sparingly soluble drugs due to high drug loading and controlled release.
Keywords:
benzydaminebetahistinebuccal drug deliverymucoadhesionmultilayer filmspolyelectrolytestolfenamic acidMore Related Videos
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