Maternal Death by COVID-19 Associated with Elevated Troponin T Levels
Johnatan Torres-Torres1,2,3, Raigam Jafet Martinez-Portilla1,2,3, Salvador Espino Y Sosa1,2,3
1Clinical Research Branch, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico.
Viruses
|February 26, 2022
Summary
Elevated troponin T in pregnant COVID-19 patients indicates a higher risk of severe pneumonia and maternal death. This biomarker is crucial for assessing prognosis in these high-risk pregnancies.
Area of Science:
- Cardiology
- Infectious Diseases
- Obstetrics & Gynecology
Background:
- Cardiomyocyte injury and elevated troponin T are linked to poor outcomes in COVID-19 patients.
- Data on this association specifically in pregnant COVID-19 patients is limited.
Purpose of the Study:
- To investigate the association between troponin T levels and adverse outcomes (viral sepsis, ICU admission, maternal death) in pregnant women with severe COVID-19.
- To establish troponin T as a prognostic marker in this population.
Main Methods:
- Prospective cohort study of pregnant women admitted to a Mexican National Institute with SARS-CoV-2 infection (October 2020 - May 2021).
- Clinical data and blood samples, including serum troponin T, were collected upon admission.
- Reverse transcription-polymerase chain reaction (RT-qPCR) confirmed SARS-CoV-2 infection.
Main Results:
- Out of 87 patients, 31 (35.63%) had severe COVID-19 pneumonia, and 6 (6.89%) experienced maternal death.
- Receiver Operating Characteristic (ROC) analysis revealed a significant association between troponin T and maternal death (AUC 0.979).
- A troponin T cutoff of 7 ng/mL predicted severe pneumonia with 83.3% detection rate at a 10% false-positive rate.
Conclusions:
- Elevated troponin T levels in pregnant women with COVID-19 are associated with an increased risk of severe pneumonia.
- Higher troponin T levels correlate with a greater likelihood of maternal death.
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