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Cryo-EM Structure of a Possum Enterovirus
Ivy Wang1, Sandeep K Gupta2, Guillaume Ems3,4
1Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 0C7, Canada.
Abstract:
Enteroviruses (EVs) represent a substantial concern to global health. Here, we present the cryo-EM structure of a non-human enterovirus, EV-F4, isolated from the Australian brushtail possum to assess the structural diversity of these picornaviruses. The capsid structure, determined to ~3 Å resolution by single particle analysis, exhibits a largely smooth surface, similar to EV-F3 (formerly BEV-2). Although the cellular receptor is not known, the absence of charged residues on the outer surface of the canyon suggest a different receptor type than for EV-F3. Density for the pocket factor is clear, with the entrance to the pocket being smaller than for other enteroviruses.
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