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Updated: Oct 2, 2025

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
Published on: May 5, 2014
Targeting Viral Methyltransferases: An Approach to Antiviral Treatment for ssRNA Viruses
1Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32603, USA.
Abstract:
Methyltransferase enzymes have been associated with different processes within cells and viruses. Specifically, within viruses, methyltransferases are used to form the 5'cap-0 structure for optimal evasion of the host innate immune system. In this paper, we seek to discuss the various methyltransferases that exist within single-stranded RNA (ssRNA) viruses along with their respective inhibitors. Additionally, the importance of motifs such as the KDKE tetrad and glycine-rich motif in the catalytic activity of methyltransferases is discussed.
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