Related Experiment Video

Updated: Oct 2, 2025

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.8K

Overcoming Radiation Resistance in Gliomas by Targeting Metabolism and DNA Repair Pathways

Wei Meng1, Joshua D Palmer1, Michael Siedow1

  • 1Department of Radiation Oncology, The Ohio State University, Columbus, OH 43210, USA.

International Journal of Molecular Sciences
|February 26, 2022
PubMed

Insights

Glioma metabolism reprogramming offers new therapeutic targets. Modulating glioma metabolism can enhance radiotherapy sensitivity and improve treatment response in brain tumors.

Area of Science:

  • Oncology
  • Cancer Biology
  • Neuro-oncology

Background:

  • Gliomas are aggressive brain tumors with significant heterogeneity.
  • Tumor cells exhibit metabolic reprogramming, a hallmark of cancer.
  • Metabolic alterations support tumor growth and therapy resistance.

Purpose of the Study:

  • To explore the role of metabolic reprogramming in glioma.
  • To discuss the link between glioma metabolism and DNA repair.
  • To investigate metabolic modulation for enhancing radiotherapy sensitivity.

Main Methods:

  • Review of transomics studies in glioma.
  • Analysis of metabolic pathways in cancer cells.
  • Discussion of interactions between metabolism, DNA repair, and radiotherapy response.

Main Results:

  • Transomics reveal widespread abnormalities in glioma biological layers.
  • Metabolic reprogramming is crucial for glioma growth and resistance.
  • Modulating glioma metabolism impacts DNA repair and radiotherapy sensitivity.

Conclusions:

  • Targeting metabolic pathways presents novel therapeutic opportunities for gliomas.
  • Understanding glioma metabolism is key to overcoming treatment resistance.
  • Metabolic modulation strategies may improve radiotherapy outcomes for brain tumors.
Keywords:
DNA repaircancer metabolismgliomasradiation resistance

More Related Videos

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes08:32

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

547
Combination Radiotherapy in an Orthotopic Mouse Brain Tumor Model08:02

Combination Radiotherapy in an Orthotopic Mouse Brain Tumor Model

Published on: March 6, 2012

16.6K

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.9K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.0K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K