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A Polyaniline-based Sensor of Nucleic Acids
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Overcoming Major Barriers to Developing Successful Sensors for Practical Applications Using Functional Nucleic Acids.

JingJing Zhang1, Tian Lan2, Yi Lu3

  • 1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, China;

Annual Review of Analytical Chemistry (Palo Alto, Calif.)
|February 26, 2022
PubMed
Summary

Developing practical sensors for environmental and medical use faces barriers. Functional nucleic acid sensors offer solutions, overcoming challenges in receptor generation, selectivity, signal transduction, and dynamic range for wider application.

Keywords:
(bio)sensorSELEXdiagnosticfunctional nucleic acidsimagingportable meter

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Area of Science:

  • Biotechnology
  • Analytical Chemistry
  • Sensor Technology

Background:

  • Extensive research aims for sensitive, selective, and practical sensors for environmental, food, and medical applications.
  • Commercialization of novel sensor technologies remains limited due to development hurdles.

Purpose of the Study:

  • To identify key scientific and technical barriers hindering the development of practical sensors.
  • To review functional nucleic acid-based sensors as a viable solution to these barriers.

Main Methods:

  • Analysis of existing sensor development challenges, including receptor generation, selectivity, signal transduction, dynamic range, and device cost.
  • Exploration of functional nucleic acids (DNAzymes, aptamers, aptazymes) and their integration with common measurement devices.

Main Results:

  • Identified five major barriers: general receptor generation, selectivity enhancement, signal transduction, dynamic range tuning, and high device development costs.
  • Demonstrated that functional nucleic acid sensors address these barriers effectively.

Conclusions:

  • Functional nucleic acid sensors offer a promising platform to overcome existing challenges in sensor development.
  • Coupling these sensors with widely available devices can lower costs and facilitate field and point-of-care applications.