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Subjective versus objective performance in people with multiple sclerosis using the MSReactor computerised cognitive

Daniel Merlo1, Tomas Kalincik2, Chao Zhu1

  • 1Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Australia.

Multiple Sclerosis and Related Disorders
|February 26, 2022
PubMed
Summary

People with multiple sclerosis (MS) often perceive cognitive changes, but these subjective reports weakly correlate with objective performance on computerised tests. Depression is linked to how individuals with MS perceive their cognitive function.

Keywords:
AttentionCognitive dysfunctionInformation processingMultiple sclerosisSubjective healthWorking memory

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Area of Science:

  • Neuroscience
  • Psychology
  • Clinical Medicine

Background:

  • Perceived cognitive impairment in multiple sclerosis (MS) is linked to negative life impacts.
  • Previous studies show links between perceived cognitive issues and objective functioning/mood.
  • No prior studies compared subjective cognitive performance with objective results in MS using a computerised battery.

Purpose of the Study:

  • To compare subjective cognitive performance with objective performance in individuals with MS.
  • To investigate the relationship between perceived cognitive function and objective measures.
  • To explore associations between subjective cognitive reports and mood/quality of life in MS.

Main Methods:

  • Participants with MS underwent serial testing on the MSReactor computerised cognitive platform.
  • The platform assessed psychomotor processing speed, attention, and working memory via reaction time tasks.
  • Subjective cognitive performance, depression, anxiety, and quality of life were collected and analyzed using Kendalls rank coefficient.

Main Results:

  • Subjective overall cognitive performance showed weak correlation with the working memory task.
  • Subjective performance correlated weakly with depression, but not anxiety or quality of life.
  • Subjective reaction speed and accuracy showed weak correlations with objective measures of processing speed, attention, and working memory.

Conclusions:

  • Perceived cognitive performance in MS patients weakly correlates with objective changes measured by MSReactor.
  • Depression is associated with how individuals with MS report their subjective cognitive performance.
  • A person's perception of their cognitive abilities in MS is only weakly linked to objective cognitive changes detected by the MSReactor system.