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HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

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Perceptual pathways to hallucinogenesis.

Andrew D Sheldon¹, Eren Kafadar¹, Victoria Fisher¹

¹Yale University School of Medicine and the Connecticut Mental Health Center, New Haven, CT, United States of America.

Schizophrenia Research

|February 26, 2022

Summary

This summary is machine-generated.

Computational psychiatry models explain hallucinations by linking them to latent states. This research explores why these states arise, aiming for precision treatments for psychotic symptoms and improved psychiatric classification.

Keywords:

Computational psychiatry Hallucinations Perception Predictive coding

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Area of Science:

Computational psychiatry
Neuroscience
Cognitive science

Background:

Computational psychiatry offers insights into neural and cognitive bases of psychotic symptoms.
Bayesian inference models show promise in explaining hallucinations by linking them to latent states and altered perceptual processing.

Purpose of the Study:

To investigate the origins and mechanisms of latent states driving hallucinations.
To explore how individual differences in these processes can inform precision treatments for hallucinations.
To integrate diverse findings on psychotic symptoms into a unified computational framework.

Main Methods:

Leveraging specific models of Bayesian inference to analyze components contributing to hallucination development.
Developing a unifying computational framework to synthesize existing research on psychotic symptoms.

Main Results:

Identified potential components within Bayesian inference models that may lead to the development of hallucinations.
Established a common framework for understanding disparate findings related to psychotic symptoms.

Conclusions:

Suggests future research directions for refining computational models of hallucinations.
Proposes a more precise psychiatric nosology based on identifiable information processing abnormalities.
Highlights the potential for precision psychiatry in treating hallucinations.