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Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

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Leveraging biomaterials for enhancing T cell immunotherapy.

Ziyan Liao¹, Wentao Zhang¹, Hanqi Zheng¹

¹Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society

|February 26, 2022

Summary

Biomaterials can improve T cell therapy for diseases like cancer by enhancing cell proliferation, delivery, and reducing side effects. This review explores biomaterial strategies for better T cell immunotherapy outcomes.

Keywords:

Biomaterials Drug delivery Immunotherapy T cell delivery

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Area of Science:

Immunology
Biomaterials Science
Therapeutic Development

Background:

T cell therapy shows promise for cancer, autoimmune diseases, and transplant rejection.
Clinical T cell therapy faces challenges like manufacturing complexity, off-target effects, and poor cell survival.
Biomaterials offer solutions to overcome these limitations in T cell-based treatments.

Discussion:

Biomaterials can be designed to promote T cell proliferation and expansion.
Strategies exist for biomaterials to enhance local T cell enrichment and retention at target sites.
Biomaterials can mitigate adverse effects associated with T cell therapies.

Key Insights:

Review details biomaterial design strategies for T cell expansion, enrichment, and delivery.
Biomaterials significantly impact T cell proliferation, localization, and therapeutic efficacy.
Optimized biomaterial-application can enhance T cell persistence and reduce toxicity.

Outlook:

Biomaterials hold substantial potential for advancing T cell immunotherapy.
Further research into novel biomaterial designs can unlock new therapeutic avenues.
Integrating biomaterials is crucial for the future success of T cell-based treatments.