Platelet-derived growth factor signalling in neurovascular function and disease
Susan Ys Li1, Rebecca Johnson1, Leon Cd Smyth2
1Department of Pharmacology and Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
The International Journal of Biochemistry & Cell Biology
|February 26, 2022
Summary
Platelet-derived growth factors are vital for brain blood vessel health. Dysregulation of this pathway is linked to neurological diseases like stroke, Alzheimer's, and brain tumors, indicating therapeutic potential.
Area of Science:
- Neuroscience
- Vascular Biology
- Cell Signaling
Background:
- Platelet-derived growth factors (PDGFs) are crucial for cerebrovascular development and maintaining brain blood vessel function.
- Aberrant PDGF signaling is implicated in neurological disorders characterized by neuroinflammation and neurovascular dysfunction.
Purpose of the Study:
- To review the role of PDGFs in neurovascular function and perivascular cell regulation.
- To explore the connection between PDGF signaling abnormalities and neurological diseases.
- To highlight the therapeutic potential of PDGF pathways in central nervous system disorders.
Main Methods:
- This is a review article, synthesizing existing research.
- Literature search on PDGF signaling, neurovascular function, and neurological diseases.
- Analysis of studies focusing on PDGF receptors and their cellular targets.
Main Results:
- PDGFs regulate perivascular cells, impacting neurovascular homeostasis.
- Signaling pathway dysregulation is associated with stroke, Alzheimer's disease, and glioblastoma.
- The angiogenic properties of PDGFs are relevant in brain tumor growth.
Conclusions:
- PDGF signaling is a key regulator of neurovascular health and disease.
- Targeting PDGF pathways offers potential therapeutic strategies for CNS diseases.
- Further research is warranted to fully elucidate PDGF's role in neurological pathologies.
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