Related Experiment Video

Updated: Oct 2, 2025

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
09:40

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function

Published on: April 17, 2020

13.9K

Predictors of anastomotic strictures following œsophageal atresia repair

Madeleine Aumar1,2, Rony Sfeir3, Adeline Pierache4

  • 1Univ Lille, CHU Lille, Reference Centre for Chronic and Malformative Esophageal Diseases (CRACMO), Inserm U1286 Infinite, CHU Lille Pôle Enfant, Lille, France madeleine.aumar@chru-lille.fr.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|February 26, 2022
PubMed

Insights

Anastomosis under tension and delayed procedures are key risk factors for esophageal strictures in infants with esophageal atresia. These factors also increase the risk of recurrent and refractory strictures, impacting surgical outcomes.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Congenital Abnormalities

Background:

  • Esophageal atresia (OA) is a congenital condition requiring surgical repair.
  • Anastomotic strictures are a common complication following OA repair.
  • Identifying risk factors is crucial for improving patient outcomes.

Purpose of the Study:

  • To determine risk factors for anastomotic, refractory, and recurrent strictures in infants with OA.
  • To investigate the association between anastomotic stricture and antireflux surgery.

Main Methods:

  • Prospective national multicenter study over 8 years.
  • Inclusion of all infants born with OA.
  • Data collection at birth and 1 year; univariate and multivariate analyses.

Main Results:

  • 23.2% prevalence of anastomotic stricture at 1 year.
  • Anastomosis under tension and delayed anastomosis are independent risk factors for strictures.
  • Higher rates of fundoplication in patients with anastomotic strictures.

Conclusions:

  • Anastomosis under tension and delayed anastomosis significantly increase the risk of esophageal strictures.
  • These factors are associated with increased rates of recurrent and refractory strictures.
  • Findings highlight the importance of surgical technique and timing in OA repair.
Abstract

Keywords:
epidemiologygastroenterologyneonatologypaediatrics

More Related Videos

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy04:05

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy

Published on: August 22, 2025

100
Vessel-sparing Excision and Primary Anastomosis08:09

Vessel-sparing Excision and Primary Anastomosis

Published on: January 7, 2019

11.6K

Related Concept Videos

Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
307
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
183
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
166
Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
196
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
251
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
41