Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

43
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
43
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

972
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
972
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

1.4K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.4K
Cardiac Catheterization IV: Nursing Management01:26

Cardiac Catheterization IV: Nursing Management

240
Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...
240
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

39
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
39
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

33
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
33

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aortic valve neocuspidization for a low-birth-weight neonate with severe aortic stenosis with regurgitation.

JTCVS techniques·2026
Same author

Valve Oversizing and Geometric Factors in Structural Valve Deterioration After Pulmonary Valve Replacement.

The Annals of thoracic surgery·2026
Same author

Dislodgement of a subcutaneous shock lead owing to loop release in the device pocket in a pediatric patient with congenital long QT syndrome.

HeartRhythm case reports·2026
Same author

Pediatric dilated cardiomyopathy caused by TNNT2-R151W mutation: Modeling and rescue in patient-derived induced pluripotent stem cells and engineered heart tissue.

Bioengineering & translational medicine·2026
Same author

Comparative Long-Term Outcomes of Anatomical and Physiological Repair for Corrected Transposition.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same author

Cardiac Resynchronization Therapy for Failing Single Ventricle Physiology.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026

Related Experiment Video

Updated: Oct 2, 2025

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
06:59

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis

Published on: August 26, 2025

104

Anticoagulation Therapy After the Fontan Procedure.

Koji Miwa1, Shigemitsu Iwai2, Toshiaki Nagashima2

  • 1Department of Cardiovascular Surgery, Osaka Women's and Children's Hospital, 840 Murodocho, Izumi, Osaka, 594-1101, Japan. komiwa0712@gmail.com.

Pediatric Cardiology
|February 26, 2022
PubMed
Summary

For children with low thromboembolism risk after the Fontan procedure, using only oral antiplatelets like aspirin is a reasonable approach. This strategy avoids warfarin, reducing bleeding risks while maintaining low rates of thromboembolic events.

Keywords:
Anticoagulation therapyAspirinBleedingFontan procedureThromboembolismWarfarin

More Related Videos

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.6K
Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
10:52

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence

Published on: December 23, 2022

3.9K

Related Experiment Videos

Last Updated: Oct 2, 2025

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
06:59

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis

Published on: August 26, 2025

104
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.6K
Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
10:52

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence

Published on: December 23, 2022

3.9K

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Surgery
  • Pharmacology

Background:

  • The optimal anticoagulation strategy post-Fontan procedure is not well-defined.
  • Warfarin use in children carries significant bleeding risks.
  • Antiplatelet monotherapy is being explored as an alternative.

Purpose of the Study:

  • To evaluate the safety and efficacy of using only oral antiplatelets (aspirin) without warfarin in pediatric patients after the Fontan procedure.
  • To assess the rates of thromboembolic and bleeding events in this patient cohort.

Main Methods:

  • Retrospective review of 249 patients undergoing the Fontan procedure.
  • Analysis of anticoagulation regimens (aspirin alone vs. aspirin with warfarin).
  • Comparison of thromboembolic and bleeding event rates between groups.

Main Results:

  • Zero hospital mortality and no early deaths related to bleeding or thromboembolism.
  • Low rates of late thromboembolic events (expected 93.4% freedom at 20 years).
  • Low rates of bleeding events, with most occurring in patients on aspirin alone (expected 88.4% freedom at 20 years).

Conclusions:

  • Continuous oral antiplatelet monotherapy (aspirin) is a reasonable prophylactic approach for low-risk pediatric patients post-Fontan procedure.
  • This strategy appears effective in preventing thromboembolic events while minimizing bleeding complications.
  • Further research may refine anticoagulation guidelines for Fontan survivors.