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Nanotechnological approaches for pentamidine delivery
Ilaria Andreana1, Valeria Bincoletto1, Paola Milla1
1Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125, Turin, Italy.
Drug Delivery and Translational Research
|February 26, 2022
Summary
Pentamidine (PTM) drug delivery faces challenges due to side effects. Nanosystems offer a promising solution for targeted PTM delivery, improving efficacy and reducing toxicity for various diseases.
Area of Science:
- Nanomedicine
- Drug Delivery
- Pharmacology
Background:
- Pentamidine (PTM) is an antimicrobial diamine with an unclear mechanism of action.
- PTM shows potential for treating mental illnesses, myotonic dystrophy, diabetes, and tumors.
- Systemic PTM administration causes severe side effects, notably nephrotoxicity.
Purpose of the Study:
- To review available approaches for designing Pentamidine nanoparticulate delivery systems.
- To emphasize formulation strategies and in vitro/in vivo applications of PTM nanocarriers.
- To provide a critical perspective on future nanomedicine developments for PTM applications.
Main Methods:
- Review of literature on polymeric, lipidic, and inorganic nanocarriers for PTM delivery.
- Analysis of formulation strategies for PTM-loaded nanoparticles.
- Evaluation of in vitro and in vivo studies on PTM nanodelivery systems.
Main Results:
- Various nanosystems leverage PTM's positive charge for efficient delivery.
- Nanoparticulate systems are in different stages of development for PTM applications.
- Formulation strategies and applications are key considerations for PTM nanodelivery.
Conclusions:
- Nanosystems are crucial for overcoming PTM's systemic administration limitations.
- Targeted PTM delivery via nanocarriers can mitigate side effects and enhance therapeutic potential.
- Future nanomedicine advancements hold promise for PTM repurposing and expanded clinical use.
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