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Abnormal Proliferation02:23

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Updated: Oct 2, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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TP53 mutations in head and neck cancer.

Cherie-Ann Nathan1, Alok R Khandelwal1, Gregory T Wolf2

  • 1Department of Otolaryngology-Head and Neck Surgery, Louisiana State University-Health Shreveport, Shreveport, Louisiana, USA.

Molecular Carcinogenesis
|February 26, 2022
PubMed
Summary

TP53 gene mutations are common in aggressive head and neck squamous cell carcinomas (HNSCCs). These mutations impact tumor behavior and patient survival, highlighting their importance in HNSCC research.

Keywords:
HNSCCTCGATP53

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Area of Science:

  • Oncology
  • Genetics
  • Cancer Research

Background:

  • Head and neck squamous cell carcinomas (HNSCCs) are aggressive, heterogeneous tumors.
  • Key etiological factors include alcohol, tobacco, and HPV infection.
  • Current treatments involve surgery, radiotherapy, and chemotherapy.

Purpose of the Study:

  • To review the current evidence and impact of TP53 mutations in HNSCC.
  • To highlight the role of TP53 mutations in HNSCC aggressiveness and patient outcomes.

Main Methods:

  • Review of comprehensive integrative genomic analysis of HNSCC.
  • Analysis of the association between TP53 mutations and clinical outcomes.

Main Results:

  • TP53 mutations are the most frequent somatic genomic alterations in HNSCC.
  • TP53 mutations are linked to tumor invasion, metastasis, genomic instability, and proliferation.
  • Disruptive TP53 mutations correlate with HNSCC aggressiveness and reduced survival post-surgery.

Conclusions:

  • TP53 mutations significantly influence HNSCC behavior and patient prognosis.
  • Understanding TP53's role is crucial for developing targeted therapies for HNSCC.