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What Do We Currently Know About Chronic Myeloid Leukemia (CML) and COVID-19?

Nancy Delgado1, Anahí Torres2

  • 1Department of Hematology, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. deln8@hotmail.com.

Current Oncology Reports
|February 26, 2022
PubMed

Insights

Patients with chronic myeloid leukemia (CML) do not appear to have a higher risk of COVID-19 infection. Tyrosine kinase inhibitors (TKIs) may play a role in managing COVID-19 in CML patients.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Oncology

Background:

  • COVID-19, a pandemic declared by WHO, presents management challenges for leukemia patients.
  • Chronic myeloid leukemia (CML) is a type of cancer affecting white blood cells.

Purpose of the Study:

  • To review current information on chronic myeloid leukemia (CML) and COVID-19.
  • To explore risk factors, prognosis, and the role of tyrosine kinase inhibitors (TKIs) in CML patients with COVID-19.

Main Methods:

  • Literature review of studies on CML and COVID-19.
  • Analysis of risk factors and outcomes for CML patients diagnosed with SARS-CoV-2 infection.

Main Results:

  • No current data indicates CML-chronic phase (CML-CP) patients face increased SARS-CoV-2 infection risk compared to the general population.
  • Tyrosine kinase inhibitors (TKIs) have been investigated for potential therapeutic roles in COVID-19.
  • CML patients with COVID-19 should continue their TKI therapy.

Conclusions:

  • Current evidence does not suggest an elevated risk of COVID-19 in CML patients.
  • Further large-scale studies are needed to confirm the protective role of TKIs against SARS-CoV-2 in CML patients.
Abstract

Keywords:
COVID-19Chronic myeloid leukemiaImatinibPandemicTreatmentTyrosine kinase inhibitors

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