Reactive hyperaemia augments local heat-induced skin hyperaemia
Natalia S Lima1, Elizabeth C Lefferts1,2, Philip S Clifford1
1Integrative Physiology Laboratory, University of Illinois at Chicago, Chicago, Illinois, USA.
Experimental Physiology
|February 26, 2022
Summary
Reactive hyperemia combined with local heating significantly enhances skin blood flow and vasodilation compared to either method alone. This finding demonstrates that reactive hyperemia can augment heat-induced hyperemia in skin microcirculation.
Area of Science:
- Physiology
- Microcirculation
- Vascular Function
Background:
- Skin microcirculation monitoring is crucial for assessing disease or treatment effects.
- Laser Doppler flowmetry (LDF) offers non-invasive monitoring of skin microcirculation.
- Heat hyperaemia (HH) is a common method to assess microvascular function.
Purpose of the Study:
- To investigate if reactive hyperaemia (RH) augments the increase in skin blood flow induced by local heating.
- To evaluate the combined effect of RH and HH on skin vasodilation.
Main Methods:
- Utilized Laser Doppler Flowmetry (LDF) to measure skin blood flow.
- Applied local heating (42°C for 40 min) to induce heat hyperaemia (HH).
- Induced reactive hyperaemia (RH) via cuff inflation (220 mmHg for 5 min) with and without local heating.
Main Results:
- Both HH and RH individually increased skin blood flow (LDF) and cutaneous vascular conductance (CVC).
- The combination of HH and RH (HH+RH) resulted in significantly greater increases in LDF and CVC compared to HH or RH alone.
- This indicates a synergistic effect of combining RH and HH.
Conclusions:
- Reactive hyperaemia can augment local heat-induced hyperaemia in the skin.
- Combining RH with HH provides a more pronounced vasodilatory response than either stimulus individually.
- This combined approach may offer enhanced insights into microvascular function.
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