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Polyvalent polymeric drug carriers.

M Vert

    Critical Reviews in Therapeutic Drug Carrier Systems
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Polymeric drug carriers, including copolymers, offer advanced solutions for controlled drug delivery and reduced toxicity. These systems effectively solubilize, transport, and release lipophilic drugs, enhancing pharmaceutical applications.

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    Area of Science:

    • Polymer chemistry and pharmaceutical sciences.
    • Drug delivery systems and nanomedicine.

    Background:

    • Synthetic polymers are widely explored for drug-carrier systems.
    • Existing systems aim for time-controlled delivery, targeting, and reduced toxicity of active compounds.

    Purpose of the Study:

    • To examine prerequisites for polymeric drug carriers.
    • To highlight the need for polyvalent systems for diverse drug carriage.
    • To focus on copolymer capabilities for solubilizing and delivering lipophilic drugs.

    Main Methods:

    • Review of polymeric microcapsules, microspheres, nanoparticles, and emulsions.
    • Focus on amphiphilic block-copolymers and partially quaternized polytertiary amines.
    • Analysis of hydrophobic microdomain formation in aqueous media.

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    Main Results:

    • Copolymers can form hydrophobic microdomains suitable for drug encapsulation.
    • These microphases demonstrate capability in solubilizing, carrying, and releasing lipophilic drugs.
    • Recent examples illustrate the current state of the art in polymeric drug delivery.

    Conclusions:

    • Polymeric drug carriers, particularly copolymers, are crucial for advanced drug delivery.
    • Amphiphilic block-copolymers and related materials show significant promise for lipophilic drug formulations.
    • Further research and application of these systems can optimize pharmaceutical uses.