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ESCMID COVID-19 guidelines: diagnostic testing for SARS-CoV-2.

Paraskevi C Fragkou1, Giulia De Angelis2, Giulia Menchinelli2

  • 1First Department of Critical Care Medicine & Pulmonary Services, Evangelismos General Hospital, National and Kapodistrian University of Athens, Athens, Greece; European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses, Basel, Switzerland.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|February 26, 2022
PubMed

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Summary

These guidelines help select the best diagnostic tests for SARS-CoV-2, considering various populations and risk factors for COVID-19 diagnosis. They offer recommendations for healthcare professionals and decision-makers.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Public Health

Background:

  • The COVID-19 pandemic necessitated clear guidance on diagnostic testing for SARS-CoV-2.
  • Existing diagnostic strategies required evaluation for optimal clinical application.

Purpose of the Study:

  • To establish evidence-based guidelines for selecting the most appropriate diagnostic tests for SARS-CoV-2.
  • To provide actionable recommendations for clinicians and healthcare decision-makers.

Main Methods:

  • An ESCMID COVID-19 guidelines task force developed clinical questions using the PICO format.
  • Literature searches focused on systematic reviews, with evidence quality assessed using the GRADE-ADOLOPMENT approach.
  • Virtual panel meetings and majority voting were employed for decision-making.
Keywords:
COVID-19DiagnosisGuidelinesSARS-CoV-2Testing

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Main Results:

  • Forty-three PICO questions were addressed, encompassing diverse populations including symptomatic patients, at-risk individuals, asymptomatic cases, and close contacts.
  • Considerations included specific diagnostic tests (NAATs, antigen tests), sample types, timing, patient age, and disease severity.
  • Recommendations were formulated based on the synthesized evidence.

Conclusions:

  • The guidelines provide a framework for choosing optimal SARS-CoV-2 diagnostic approaches.
  • These recommendations aim to improve the accuracy and efficiency of COVID-19 diagnosis in various clinical scenarios.
  • The study supports informed decision-making in SARS-CoV-2 testing strategies.