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DOES TITANIUM TETRAFLUORIDE PROMOTE A PROTECTIVE EFFECT ON ERODED TOOTH? A SYSTEMATIC REVIEW AND META-ANALYSIS
Rodrigo Barros Esteves Lins1, Marina Rodrigues Santi1, Mayara Dos Santos Noronha1
1Department of Restorative Dentistry, Operative Dentistry Division, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil.
The Journal of Evidence-Based Dental Practice
|February 27, 2022
Summary
Titanium tetrafluoride (TiF4) solution offers superior protection against enamel erosion compared to sodium fluoride (NaF). However, both TiF4 and NaF varnishes provide similar protection for eroded enamel and dentin.
Area of Science:
- Dental materials science
- Biomaterials
- Oral health research
Background:
- Dental erosion is a significant concern, leading to mineral loss in enamel and dentin.
- Fluoride compounds are widely used to prevent and treat dental erosion.
- Titanium tetrafluoride (TiF4) is a potential alternative to sodium fluoride (NaF) for dental applications.
Purpose of the Study:
- To systematically review and meta-analyze the protective effects of TiF4 compared to NaF on eroded enamel and dentin.
- To evaluate the efficacy of TiF4 and NaF in different delivery forms (solution vs. varnish).
Main Methods:
- A comprehensive literature search was conducted across multiple databases up to June 2020.
- In vitro studies evaluating mineral loss in eroded enamel or dentin treated with TiF4 or NaF were included.
- Four meta-analyses were performed based on the delivery form and substrate (enamel/dentin), with risk of bias assessment.
Main Results:
- Twenty-two studies were included in the systematic review, with most classified as medium or high risk of bias.
- Four meta-analyses revealed considerable heterogeneity.
- Titanium tetrafluoride solution showed statistically significant protection for enamel erosion compared to NaF.
Conclusions:
- Titanium tetrafluoride solution demonstrates superior protective effects on eroded enamel compared to sodium fluoride.
- Both TiF4 and NaF varnishes exhibit comparable protective efficacy on eroded enamel and dentin.
- Further research may be needed to address the heterogeneity observed in the meta-analyses.
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