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Updated: Oct 2, 2025

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
Published on: November 15, 2024
Glucose-derived posttranslational modification in cardiovascular disease
Michael Lehrke1, Julia Moellmann1, Florian Kahles1
1Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Aachen, Germany.
Abstract:
Glucose and its metabolites provide building blocks for cellular structures and modifications occurring on proteins, lipids and nucleotides. The underlying reactions consist of glycosylations controlled by hundreds of enzymes following a specific yet incompletely understood architecture of cell physiology and glycations as random, not controlled modifications occurring in an oxidative environment. In both cases attachments of glucose or its metabolites can modulate the tertiary structure of proteins as required for cellular physiology or cause disturbance with disease driving pathology. In this review we will discuss the relevance of glucose dependent cellular modifications for cardiovascular complications.
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