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Thrombosis in patients with post-polycythemia vera myelofibrosis: incidence and risk factors

Guangshuai Teng1, Yuan Zhou2, Yuhui Zhang1

  • 1Department of Hematology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China.

Thrombosis Research
|February 27, 2022
PubMed
Abstract

Insights

Patients with post-polycythemia vera myelofibrosis experience a high incidence of thrombosis. Key risk factors include palpable splenomegaly, age over 60, and a history of thrombosis.

Area of Science:

  • Hematology
  • Oncology
  • Thrombosis Research

Background:

  • Post-polycythemia vera myelofibrosis (Post-PV MF) represents an advanced stage of polycythemia vera (PV).
  • Thrombosis is a significant cause of morbidity and mortality in PV patients.
  • Characteristics of thrombosis in Post-PV MF remain under-explored.

Purpose of the Study:

  • To characterize thrombosis in patients with Post-PV MF.
  • To identify risk factors associated with thrombosis in this patient population.

Main Methods:

  • Analysis of clinical and laboratory data from 163 Post-PV MF patients.
  • Kaplan-Meier and multivariate Cox regression analyses to determine thrombosis risk factors.

Main Results:

  • Over half (51.5%) of patients developed thrombosis during follow-up.
  • Thrombosis-free survival (TFS) was significantly lower in Post-PV MF compared to PV.
  • Independent risk factors for thrombosis included palpable splenomegaly, age ≥ 60 years, and a history of thrombosis.

Conclusions:

  • Post-PV MF patients exhibit an elevated incidence of thrombosis.
  • Palpable splenomegaly, older age, and prior thrombosis are significant independent risk factors.
  • Risk stratification models predict varying TFS based on identified risk factors.
Keywords:
Post-polycythemia vera myelofibrosisRisk factorThrombosis

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