Non-invasive localization of premature ventricular focus: A prospective multicenter study

Area of Science:

• Cardiology
• Medical Imaging
• Electrophysiology

Background:

• Accurate localization of premature ventricular contractions (PVC) focus is crucial for successful catheter ablation.
• Identifying the anatomical origin of PVCs guides therapeutic interventions.

Purpose of the Study:

• To evaluate the accuracy of the View Into Ventricular Onset (VIVO) software in determining the anatomical origins of premature ventricular contractions (PVCs).
• To compare VIVO-predicted PVC origins with invasive electroanatomical mapping results.

Main Methods:

• 51 patients undergoing PVC ablation were recruited.
• VIVO system created a noninvasive heart model and applied algorithms to predict PVC origins.
• VIVO predictions were compared to invasive electroanatomical activation mapping and pacing locations, adjudicated by blinded experts.

Main Results:

• The VIVO system accurately identified the origin of clinical premature ventricular contractions in 100% of analyzed patients (44/44).
• The accuracy for identifying paced locations (right and left ventricles) was 99.5%.
• No adverse events were associated with the VIVO system during the study.

Conclusions:

• The VIVO system is a novel, noninvasive tool demonstrating high accuracy for guiding ventricular arrhythmia ablation procedures.
• The VIVO algorithm's ease of use suggests its potential utility in the clinical workflow for ablation therapy.