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Updated: Oct 2, 2025

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
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The chromosome 21 kinase DYRK1A: emerging roles in cancer biology and potential as a therapeutic target

Malini Rammohan1, Ethan Harris2,3, Rahul S Bhansali4

  • 1Driskill Graduate Program in Life Sciences, Northwestern University, Chicago, IL, USA.

Oncogene
|February 27, 2022
PubMed

Insights

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) impacts cancer by regulating key processes like cell cycle and DNA repair. Its dual role as an oncogene or tumor suppressor highlights context-dependent therapeutic potential.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • DYRK1A is a serine/threonine kinase in the CMGC superfamily, located on chromosome 21.
  • Initially studied in Down syndrome, DYRK1A's role in cancer is increasingly recognized.

Purpose of the Study:

  • To review the mechanistic contributions of DYRK1A in cancer biology.
  • To explore DYRK1A as a potential therapeutic target in oncology.

Main Methods:

  • Literature review of DYRK1A's functions in cancer.
  • Analysis of DYRK1A's role in cell cycle, DNA repair, transcription, and stem cell maintenance.

Main Results:

  • DYRK1A regulates critical cancer-related processes including cell cycle progression and DNA damage repair.
  • DYRK1A functions as both an oncogene and a tumor suppressor, depending on cellular context.

Conclusions:

  • DYRK1A plays a multifaceted role in cancer development and progression.
  • Targeting DYRK1A presents a potential therapeutic strategy, requiring consideration of its context-dependent function.

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