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Survival following lung transplantation: A population-based nested case-control study
John Iguidbashian1, Jake Cotton1, Robert W King1
1Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA.
Journal of Cardiac Surgery
|February 27, 2022
Summary
Lung transplant recipients have a fivefold higher mortality rate than the general population, but survival has improved over time. This study analyzed survival and standardized mortality ratios (SMRs) in lung transplant patients.
Area of Science:
- Cardiology and Thoracic Surgery
- Transplantation Medicine
- Public Health and Epidemiology
Background:
- Lung transplantation is a critical treatment for end-stage respiratory failure.
- Assessing long-term survival and mortality risks post-transplant is essential.
Purpose of the Study:
- To evaluate survival rates of lung transplant recipients compared to the general population.
- To quantify standardized mortality ratios (SMRs) in this cohort.
Main Methods:
- A nested case-control study design was employed.
- 14,977 lung transplant recipients were propensity-matched to 74,885 controls from the National Longitudinal Mortality Study.
- The primary endpoint was 10-year survival.
Main Results:
- The 10-year survival rate for lung transplant recipients was 28%.
- Lung transplant recipients had an SMR of 5.39, indicating a 5.39 times higher mortality rate than the general population.
- Higher SMRs were observed in females, Hispanic recipients, and single lung recipients, with SMRs declining over time.
Conclusions:
- Lung transplant recipients face significantly higher mortality risks compared to the general population.
- There has been a consistent decline in long-term mortality rates over time, suggesting improved outcomes.
