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Updated: Oct 2, 2025
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Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
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Intermittent time-restricted feeding promotes longevity through circadian autophagy
Zhangyuan Yin1, Daniel J Klionsky1
1Life Sciences Institute, and the Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Autophagy
|February 28, 2022
Summary
Intermittent time-restricted feeding extends lifespan and healthspan in flies by activating autophagy during the night. This circadian-regulated autophagy is key to the anti-aging benefits of this dietary strategy.
Area of Science:
- Cellular Biology
- Aging Research
- Chronobiology
Background:
- Macroautophagy/autophagy is vital in aging and age-related diseases.
- Autophagy-related genes are essential for anti-aging interventions across species.
- Circadian rhythms influence numerous physiological processes, including cellular maintenance.
Discussion:
- A novel intermittent time-restricted feeding (iTRF) regimen extends fly healthspan and lifespan.
- iTRF's benefits are mediated by the circadian rhythm-dependent activation of autophagy.
- Night-specific autophagy induction is both necessary and sufficient for iTRF's health benefits.
Key Insights:
- Autophagy plays a critical role in the aging process.
- Dietary interventions like iTRF can modulate autophagy for anti-aging effects.
- The timing of autophagy activation (night-specific) is crucial for healthspan and lifespan extension.
Outlook:
- Future research can explore behavioral or pharmaceutical strategies to promote night-specific autophagy.
- Targeting night-specific autophagy may offer new avenues for promoting healthy aging.
- Understanding the molecular links between circadian rhythms and autophagy can unlock novel anti-aging therapies.
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