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Black Phosphorous Aptamer-based Platform for Biomarker Detection.

Ajinkya Nene¹, Shengyong Geng¹, Wenhua Zhou¹

¹Materials Interfaces Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China.

Current Medicinal Chemistry

|February 28, 2022

Summary

This summary is machine-generated.

Black phosphorus nanostructures (nano-BPs) offer unique properties for biosensing applications. This review highlights stable nano-BP-aptamer conjugates for early disease diagnosis and management.

Keywords:

Black phosphorous aptamer bio-sensing biomarkers cardiovascular disorders stability

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Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Black phosphorus nanostructures (nano-BPs), including nanosheets and quantum dots, have emerged as popular nanomaterials since 2014.
Nano-BPs exhibit advantageous properties such as high surface area, excellent photothermal conversion, biocompatibility, high charge carrier mobility, and thermal conductivity.
These characteristics position nano-BPs as highly promising for various applications, including biosensing platforms, photothermal/drug delivery, and energy devices.

Approach:

This review discusses synthesis methods for nano-BPs to understand their development.
It focuses on achieving stable black phosphorus (BP) and BP-aptamer conjugates for biosensing.
The review examines BP-aptamer-based platforms for detecting disease biomarkers.

Key Points:

Nano-BPs possess properties ideal for biosensing platforms.
Stable BP-aptamer conjugates are crucial for successful biosensing applications.
BP-aptamer platforms show potential in detecting cardiovascular diseases and cancer markers.

Conclusions:

Black phosphorus nanostructures are versatile materials with significant potential in biosensing.
The development of stable BP-aptamer conjugates is key to advancing disease diagnosis and management.
Further research into BP-aptamer platforms can lead to improved early detection and treatment strategies.