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Tropheryma whipplei in the stool samples of children with acute diarrhea: a study from Tehran, Iran

Shirin Sayyahfar1, Mina Latifian2,3, Parisa Esmaeili2,3

  • 1Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.

BMC Infectious Diseases
|February 28, 2022
PubMed

Insights

Tropheryma whipplei was detected in Iranian children with acute diarrhea, suggesting its role in the condition. This finding highlights the need for healthcare awareness regarding T. whipplei infections in childhood diarrhea.

Area of Science:

  • Microbiology
  • Pediatrics
  • Infectious Diseases

Background:

  • Tropheryma whipplei is a suspected cause of childhood diarrhea globally.
  • Data on T. whipplei prevalence in Iranian children with diarrhea is limited.
  • This study investigated T. whipplei in children experiencing acute diarrhea in Iran.

Purpose of the Study:

  • To determine the prevalence of Tropheryma whipplei in children with acute diarrhea in Iran.
  • To assess the association between T. whipplei and the duration of diarrhea in pediatric patients.

Main Methods:

  • Stool samples were collected from 130 children under 10 years old with acute diarrhea in Tehran.
  • Genomic DNA was extracted and tested for T. whipplei using SYBR Green Real-time PCR.
  • Positive samples were confirmed by PCR product sequencing.

Main Results:

  • Tropheryma whipplei DNA was detected in 9.23% (12/130) of the stool samples.
  • Diarrhea duration was significantly longer in T. whipplei-positive children (83.3%) compared to negative cases (45.8%).
  • No significant association was found between T. whipplei infection and other demographic factors or clinical signs.

Conclusions:

  • Tropheryma whipplei was identified in children with acute diarrhea in Iran.
  • The findings suggest T. whipplei may be associated with childhood diarrhea in the region.
  • Healthcare providers should consider T. whipplei in the differential diagnosis of childhood diarrhea in Iran.
Abstract

Keywords:
DiarrheasGastrointestinal DiseaseTropheryma whippleiWhipple's Disease

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