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Updated: Oct 2, 2025

Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis
Published on: December 22, 2017
Ovine Iliac Vein Model for Endovascular Thrombectomy of Acute Deep Venous Thrombosis
Ravi Tyagi1, Danyel Crout Carr2, Peter Stibbs3
1University of Illinois at Chicago College of Medicine, Chicago, Illinois. Electronic address: https://twitter.com/ravityagi200.
Abstract:
An ovine iliac vein thrombosis model was devised to test a wall-contacting rotational thrombectomy device. Thrombosis was successfully induced in 9 sheep with an average clot length of 31 mm ± 12 and >60% vessel occlusion on angiography. The thrombus was subsequently removed, maintaining normal intraoperative pulmonary arterial pressure (5.9 mm Hg ± 3.6) and complete distal reperfusion after thrombectomy. Additionally, the sheep were without signs of vascular trauma or embolic complications on gross necropsy and histopathologic analysis. The findings from this study support the use of an ovine iliac deep vein thrombosis model for testing of a lower extremity thrombectomy device.
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